Follow-up to the ECVAM Prevalidation Study on In Vitro Tests for Acute Skin Irritation ECVAM Skin Irritation Task Force Report 2
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چکیده
The European Centre for the Validation of Alternative Methods (ECVAM) Skin Irritation Task Force, established in November 1996, prepared a report on the current status of the development and validation of alternative tests for skin irritation and corrosion in 1998 (1). The report focused on the identification of appropriate non-animal tests for predicting human skin irritation, which could be considered to be sufficiently well developed for prevalidation and validation by ECVAM. At that time, it became evident that, although several in vitro methods were under development and evaluation, a test protocol, a preliminary prediction model (PM) and supporting data on several types of chemicals were available only for a test employing EpiDerm, a reconstituted human skin model, so it was proposed that the EpiDerm test should undergo prevalidation. Furthermore, in order to be able to include other in vitro tests in such a prevalidation study, the task force set a challenge to othFollow-up to the ECVAM Prevalidation Study on In Vitro Tests for Acute Skin Irritation
منابع مشابه
Optimisation of the EpiDerm test protocol for the upcoming ECVAM validation study on in vitro skin irritation tests.
An ECVAM-funded prevalidation study (PV) was conducted during 1999 and 2000 to identify in vitro tests capable of reliably distinguishing between skin irritants (I) and non-irritants (NI) according to European Union risk phrases ("R38" or no classification). The tests evaluated were EpiDerm, EPISKIN, PREDISKIN, the non-perfused pig ear method, and the mouse skin integrity function test (SIFT). ...
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